BIO-DIS is ideal for automatic dissolution testing of dosage forms that require different types of media. It is typically used for imitating the pH changes that occur in the body and is perfectly suited for extended and sustained release dosage forms. The BIO-DIS can automatically transport samples to another row of media, simulating the gastrointestinal changes that occur in vivo. Capable of running unattended for periods of up to six days, the BIO-DIS can store up to 15 programs and provide direct control over timepoints, agitation rate, sampling rate, movement between vessel rows, hold dip time, and drain time. The BIO-DIS is designed to meet current USP Apparatus 3 and EP Reciprocating Cylinder specifications.
Specifications
Biorelevant -Simulate gastrointestinal conditions with simple programming that allows in vitro dissolution pH profiling with biorelevant agitation rates and retention times.
Flexible- useful for release-rate testing of floating dosage forms, beads and chewables. Use one instrument to test and transport a variety of samples, saving valuable bench space. Samples are automatically transported from one medium to the next without operator intervention.
Compliant- be confident knowing the BIO-DIS is compliant with the reciprocating cylinder apparatus, USP Apparatus 3 and EP harmonized specifications.
Easily configured- select a standard volumetric reciprocating cylinder option or small and large volume configuration to meet testing needs for low dose or poorly soluble formulations. Other options include a double row instrument for increased testing throughput (the number of media changes is reduced in half with this option).
Automated Sampling- easily perform automated sampling by integrating theAgilent 850-DS Dissolution Sampling Station.
Reporting- the built-in Report Center Printer provides hard-copy documentation of testing progress and conditions. A four-line digital display provides updated operation information as the test progresses.
Software Control- available through the 21 CFR compliantDissolution Workstation Softwarewhich allows direct programming of the BIO-DIS and850-DS Dissolution Sampling Stationalong with various pumps and filter changer.
Temperature Control- maintain temperature with the standard heater/circulator. All parameters are controlled by the BIO-DIS and entered from the front panel keypad.
Dimensions (L x W x H): 27 x 27 x 29
Weight: 100 lbs
Power: 120V; 60Hz
Additional Prep Fees May Apply.
